This is The Juice, the place where everything longevity finds a home. Science, stories, laughs and stacks more

Today’s goodness will be:

• The Kings of Longevity

• Bryan Johnson’s erections

• Longevity: how to start

• Today in the Apothecary: NMN

• In the hood: Johan from the Netherlands

• Today’s confusion: HbA1c

• The Juice’s picks: The best communities for Longevity

• Microdoses: Charlie Munger’s tips for life

THE KINGS OF OUR FUTURE: Blessing or Faustian Bargain…?

In the dynamic realm of diet, longevity, and antiaging, a quartet of influential figures, Dr. Andrew Huberman, Dr. David Sinclair, Dr. Peter Attia, and Bryan Johnson, have risen to prominence, captivating millions with promises of extended lifespans and healthier living. As their influence grows, a pressing question emerges: Are these gurus steering the narrative for the collective betterment of society, or is their impact a double-edged sword veering towards personal gain?

The rapid progression of scientific knowledge in aging research, coupled with the compelling science behind supplements, drugs, and genetic engineering, promises a tantalizing prospect of life extension. As society stands at the crossroads of these advancements, a serious cocktail of change is potentially ahead.

The deep pockets of tech giants like Google and the investments of billionaires in cryogenics and futuristic technologies amplify the momentum. The convergence of science, money, and power paints a complex picture of where the trajectory of life extension is headed.

Navigating this uncharted territory underscores the need for vigilance and thoughtful consideration. The future of our world may be shaped by the interplay of science, influence, and wealth. While the intentions seem positive, where these influential figures and others could lead us remains uncertain. One thing is clear: the journey towards longevity, like AI, is a collective endeavor that requires careful navigation and introspection.

These gurus, with substantial followings, are deeply entangled in the business side of longevity, sitting on boards, owning, and investing in companies poised to reap significant benefits from the ongoing revolution. Peter Attia's exclusive clientele, including celebrities and business leaders, pay him hundreds of thousands a year for personalized guidance. Andrew Huberman, with over 4.2 million subscribers on YouTube and significant podcast listeners, enjoys sponsorships from supplement giants and corporations, raising questions about the potential impartiality of shared information. Meanwhile, Bryan Johnson, a futurist on the fringe, explores controversial treatments like penis shock therapy and using his son's blood for antiaging, pushing the boundaries of conventional approaches to longevity. These individuals have become proxies for the future health decisions of millions. The question lingers: Can they be trusted to prioritize the well-being of the masses over personal gain and are their actions driven by altruism or a hunger for fame and fortune?

While admiration abounds for these figures and the benefits gained from their knowledge, it's important to acknowledge the potential societal challenges that could arise from humans living an extra 20-50 years. Issues such as overpopulation, inequality, and ethical dilemmas loom on the horizon, adding layers of complexity to the ongoing longevity revolution. What are your thoughts on these potential societal impacts?

Our fave billionaire longevity Guinea Pig is keeping it real this week!

If the name doesn't sound familiar, you might recognize him for his ambitious quest to reverse his biological age.

Allocating a remarkable $2 million annually to his endeavor of age reversal, the 46-year-old has experimented with a range of methods, from adhering to a strict diet to exploring unconventional approaches like utilizing his son's blood.

In a recent conversation with Steven Bartlett on The Diary of a CEO podcast, Johnson unveiled his latest technique for assessing his health.

According to BJ, nighttime erections serve as a meaningful health indicator, reflecting psychological and cardiological well-being.

Previously, he noted that he was typically erect for "two hours and 12 minutes" during the night. However, he has since undergone shockwave therapy with the goal of "rebuilding" his penis to achieve "three hours and 30 minutes of nighttime erections," aiming for a level comparable to an 18-year-old.

Describing the process, Johnson mentioned sitting in a chair while his penis is subjected to shockwave therapy.

"There's this technology where you have a wand, and you sit in a chair. The technician uses the wand to administer shocks to your penis through acoustic technology. It functions similarly to workouts, creating micro-injuries to facilitate rebuilding."

While this technology is more commonly used for other body parts like knees, joints, or shoulders, it can also be applied for addressing erectile dysfunction.

Keep up the good work Bryan.

Longevity……How to get started

Embarking on a journey to live longer is daunting for most. Here’s how Daniel did it.

Meet Daniel, a 42-year-old carpenter from Australia, navigating the intricate balance of work and family life amidst the chaos of raising young children. His story is familiar for many, commencing with a seemingly typical life characterized by moderate drinking, occasional indulgences, and the unspoken assumption that health would naturally take care of itself.

Daniel’s lifestyle, leading up to his awakening moment, reflected the average person's routine. Regular exercise was part of staying fit, not a pursuit of longevity. His generally healthy diet occasionally strayed off course but was indicative of the people around him. Longevity was a distant consideration, if a consideration at all.

This was the essence of Daniel's existence—a life where health was unconsciously taken for granted, and the future was a distant horizon not requiring immediate consideration. Like many, he found comfort in the belief that he would be okay without deeply contemplating what that meant for the years ahead.

However, the abrupt onset of his father's dementia shattered this complacency, making the future a stark reality demanding attention. The fear of facing similar health challenges prompted Daniel to embark on a profound exploration of longevity, questioning assumptions and reassessing choices.

Daniel's journey into longevity began with a fundamental question: "How healthy am I really?" Collaborating with his doctor, he initiated tests unraveling his current health status, revealing high cholesterol, pre-diabetes, and the presence of the APOE4 gene—a marker linked to elevated dementia risk.

While daunting, this newfound information brought relief, lifting the veil on Daniel's health and allowing him to have more control over his situation. Subsequent tests assessing heart health indicated minimal damage at 42, emphasizing prevention and partial reversal through medication, dietary adjustments, and a focus on exercise. Dietary changes took center stage in addressing pre-diabetes and dementia risk.

Daniel’s commitment to a health-first, longevity-driven lifestyle grew, fueled by the reassurance that he was no longer unwittingly contributing to his health decline. His journey extended beyond health assessments, engaging with online longevity communities and adopting a holistic approach to ensure a high quality of life as he ages. Revamping his fitness routine, prioritizing sleep, and monitoring health with wearables, Daniel's story is an example of a proactive approach to longevity—a journey about adding vitality to added years.

Steps to Longevity: A Brief Summary

1. Acknowledge the Possibility: Step out of the status quo and be prepared for challenging change. Recognize the mental aspect as the most formidable hurdle.

2. Assess Your Baseline: Evaluate your current health situation, considering hereditary conditions. Get tested so you know your baseline to gain clarity on your risk profile.

3. Understand Your Risks: Gain information about your potential health risks and proactively address them. The longevity approach involves acting now rather than waiting until illness strikes.

4. Explore Lifestyle Changes: Delve into the world of drugs, lifestyle choices, diets, exercise, supplements, wearables, and protocols to enhance overall health and mitigate specific risks.

5. Personalize Your Approach: Tailor interventions based on your unique health profile and risk factors. Embrace a comprehensive strategy that encompasses physical, mental, and emotional well-being.

6. Commit to Continuous Improvement: Longevity is a journey, not a destination. Embrace a mindset of continuous improvement, staying informed, and adapting your approach as needed.

Daniel’s story illustrates that it's never too late to embark on a path of longevity. Through gradual, purposeful changes, one can not only address existing health concerns but also enhance the quality of life for the years to come.

NMN

Nicotinamide Mononucleotide (NMN) has ignited a fervor in the world of longevity supplements, emerging as a leading contender in the quest for the elusive fountain of youth. The precursor to nicotinamide adenine dinucleotide (NAD+), NMN has captured attention for its potential to wind back the biological clock. As NAD+ levels wane with age, NMN aims to bolster cellular energy and reignite biological processes.

The scientific data on NMN reveals promising findings. Research hints at its ability to revitalize mitochondria, enhance metabolism, and kickstart cellular repair mechanisms. While human trials continue to reveal its full potential, early results are promising.

Users of NMN report a range of benefits, from heightened energy levels to enhanced cognitive function.

In the longevity world, dosages remain a topic of intrigue and experimentation. Users often begin, with modest doses like 250 mg per day and adjust based on their body's response. Used by longevity experts like Dr David Sinclair, Dr Andrew Huberman and longevity guru Bryan Johnson, NMN is currently not available to be sold as a dietary supplement is the US and other countries even though is appears to be widely available online.

As with all supplements it’s important for individuals considering NMN supplementation to consult with a healthcare professional, as the long-term effects and optimal dosages are areas of ongoing research.

In The Hood: Stories from our community

Meet Johan from The Netherlands

How old are you? I'm now 64

What is your death number (The ideal age you will die)? 

Interesting question which I have never really thought about. I guess 85-90 would be a good place.

Can you share a specific turning point or realization that motivated you to prioritize your health and well-being?

Health was this abstract concept I never wanted to grapple with until that moment my chest tightened. A mild heart attack made me acknowledge that I needed to change or face dire consequences.

What are the greatest challenges you face to a long life? 

Undoing a lifetime of poor dietary choices and excessive alcohol consumption has been a big task. The internal damage I inflicted over the years can’t be understated.

What diet/style of eating works for you? 

I've completely overhauled my diet—no more processed junk or excessive red meat. It's all about lean proteins, loads of veggies, and whole grains. I've cut out almost all sugar and now it is a weekly treat rather than a daily need.

What do you do for physical fitness? 

Cardio is something new for me and I didn’t really even know what cardio was before all this happened. Daily walks, swimming or cycling are non-negotiable now and I also started weight training to rebuild the strength I lost during my recovery.

Do you have a supplement stack? 

To support my heart health, I take Omega-3 fatty acids, CoQ10, and then I am experimenting with NMN and Resveratrol.

What other things do you do for longevity? 

Mindfulness practices, particularly meditation, have become my anchor. It helps manage the stress that used to be drowned in alcohol. I have a cold shower most days as well.

What has had the biggest impact on your longevity to date? 

Overcoming my unhealthy relationship with food and alcohol has been transformative. It's like shedding the weight of a lifetime of bad decisions.

What role does mental health play in your overall approach to longevity, and how do you prioritize it? 

Mental health is paramount. I've learned to confront my demons, face my anxieties, and embrace each day with a newfound appreciation. Therapy has been an unexpected ally.

How do you balance the social aspects of life with your longevity goals? Socializing doesn't mean drowning myself in booze anymore and I prioritise my friends who understand and respect my journey. It's about creating new, healthier social norms.

What advice would you give to someone just starting their journey toward a longer and healthier life? 

Acknowledge the hard truths, face the discomfort, and understand that every positive change you make is a step toward a better, longer life. Your body is incredibly resilient—give it the chance to prove that to you.

Today’s confusion comes from….

HbA1c

HbA1c is a test for people who might be at risk of diabetes or pre-diabetes and is important for anyone concerned with longevity to understand if they are at risk or not.

When we eat food, our bodies break down carbohydrates into glucose, a form of sugar used for energy. In a healthy system, insulin, a hormone produced by the pancreas, helps cells absorb glucose. However, in pre-diabetes or diabetes, this process falters and can result in excessively high glucose levels potentially causing long-term health problems.

A high HbA1c diagnosis if detected early enough in most cases can be managed or even reversed.

Who is at Risk:

• Individuals with a family history of diabetes.

• People with obesity or those with a high body mass index (BMI).

• Those leading a sedentary lifestyle with little physical activity.

• Individuals with high blood pressure.

• Women with a history of gestational diabetes.

How to Improve HbA1c Levels:

1. Healthy Diet:

   • Limit the intake of sugary foods and refined carbohydrates.

   • Emphasize a balanced diet rich in whole grains, lean proteins, fruits, and vegetables.

2. Regular Exercise:

   • Engage in regular physical activity to help control blood sugar levels.

   • Aim for at least 150 minutes of moderate-intensity exercise per week.

3. Weight Management:

   • Achieving and maintaining a healthy weight can positively impact HbA1c levels.

4. Medications:

   • For those with diabetes, medications (oral medications or insulin) may be prescribed by a healthcare provider.

5. Regular Monitoring:

   • Regularly monitor blood sugar levels to make timely adjustments to the treatment plan.

It's crucial for individuals at risk or diagnosed with diabetes to work closely with healthcare professionals, including doctors and dietitians, to develop a personalized plan for managing blood sugar levels and overall health. Early intervention and lifestyle modifications can significantly improve HbA1c levels and reduce the risk of complications associated with diabetes.

The Juice’s pick:

Online Longevity Communities

For those seeking immersion and support on their longevity journey, several reputable online communities offer valuable resources. If the prospect of connecting with individuals who share a similar mission, navigating common challenges, and obtaining answers to pertinent questions is appealing, we recommend exploring the curated list of recommended communities provided below. While Reddit stands out as a prominent online hub for like-minded longevity enthusiasts, we have also included noteworthy options on Facebook.

Reddit

1. r/longevity: Dive into discussions on living longer, exploring biomedical rejuvenation, damage repair, and the latest in health research. Stay updated on advancements in stem cell therapies, gene therapy, and more for a deeper understanding of longevity.

2. r/blueprint_: Get practical tips on food prep, systems, and discipline for implementing Bryan Johnson's Blueprint. Connect with those aiming for perfect adherence to a transformative lifestyle.

3. r/Biohacker: Join a community focused on DIY biology, pharmacology, and biohacking. Share experiences and ideas with like-minded individuals exploring the world of self-optimization.

4. r/HubermanLab: Engage with fans of Dr. Andrew Huberman and the Huberman Lab Podcast. Discuss science-based tools for everyday life and stay in the loop with new podcast releases.

5. r/PeterAttia: Connect with fellow enthusiasts to discuss Peter Attia's work and The Peter Attia Drive podcast. Delve into the latest in longevity science and share thoughts on podcast episodes.

6. r/SENS: Explore discussions on combating aging through the SENS approach. Contribute to conversations about strategies addressing the root causes of aging.

7. r/QuantifiedSelf: Share insights into self-tracking and technology use for personal insights. Connect with others interested in personal data analytics and optimizing well-being.

Facebook

1. Anti Aging, Biohacking & Longevity Knowledge: Engage in discussions about anti-aging, biohacking, and longevity on this Facebook group. Connect with a community interested in optimizing health.

2. Longevity: Join discussions about increasing human lifespan in this Facebook group. Share insights, discoveries, and news related to longevity with like-minded individuals.

3. Friends of Longevity: Coordinate efforts to bring geroscience progress to the world in this Facebook group. Discuss the latest advancements in longevity and geroscience.

4. Blueprint - Bryan Johnson's Age Reversal Challenge: Connect with those actively aiming to reverse aging and improve lifespan markers in this Facebook group inspired by Bryan Johnson's Blueprint.

5. Longevity Anti Aging Tips - NMN, Resveratrol, David Sinclair Lifespan: Share news, thoughts, and personal experiences related to longevity and anti-aging in this Facebook group. Discuss topics like NAD+, NMN, resveratrol, metformin, and biohacking.

6. BioHackers (GLOBAL): Join a global community of biohackers on Facebook for discussions on health optimization, biohacking, and cutting-edge technologies. Connect with individuals passionate about pushing human potential boundaries.

Explore these communities to delve into practical discussions on longevity, biohacking, and self-optimization.

Microdoses

Charlie Mungers 6 tips to a longer life……it’s not supplements, ice baths or better sleep!

Dinosaurs and human longevity The ‘longevity bottleneck’ hypothesis

Meet Bobi the world’s oldest dog and find out what he can teach us about aging.

Live 10 years longer just by changing your diet. A UK study tells the story.

Healthy weight in a women’s 60’s…….. could this be the main factor to live to 90?

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THANKS FOR DISCOVERING LONGEVITY WITH THE JUICE

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